The Jets lost on the road up in Buffalo 27-17 and it wasn't even that close as the Bills controlled the game up 21-3 at half and costed in the second half. San Francisco gave up 14 points in the fourth quarter to lose 24-20 to Arizona at home and chomping at the bit to get back on the field and get a win under their belts. San Francisco had 259 yards passing, two touchdowns and no interceptions from Jimmy Garoppolo and over 120 yards rushing as a team, but it wasn't enough. The Jets had 215 yards passing a touchdown and an interception from Sam Darnold who was also sacked three times, Frank Gore was the leading rusher at 24 yards and the bright spot was Crowder with seven catches for 115 yards and a touchdown, but he is out with a hamstring injury. Bell is out for the Jets so it will be Gore against his former team to lead the way, but he is 37 and has 48 yards rushing in his only game against his former team. Mostert had just 56 yards rushing, but added four catches for 95 yards and a touchdown. Look for Mostert to outplay Gore as the 49ers get fat on the Jets with a 30-17 win. Play San Francisco

Houston lost the opening game of the year to Kansas City after taking a 7-0 in the first quarter they gave up 24 unanswered points on their way to losing 34-20. Baltimore dominated Cleveland in their week one match up 38-6 as Jackson went 20-25 for 275 yards and three touchdowns plus 45 yards rushing. Watson had 253 yards, one touchdown, one interception and 27 yards rushing. Baltimore has the strong offensive weapons to keep defense on their toes and a stout defense that is well rested from their offense chewing up clock. This will be a battle of Jackson vs. Watson with Jackson winning along with help from his defense coming up with big stops in the 4th quarter in a Baltimore win 37-21. Play Baltimore

New England won their first game without Brady and with Cam Newton at the helm beating the Dolphins at home 21-11 as Cam ran for two touchdowns. Seattle won 38-25 with Russell Wilson went off for for 322 yards, four touchdowns, no interceptions and was the leading rusher for Seattle at 29 yards. Wilson is 48-16 at home in his career and 2-0 in his career against New England with six touchdowns and no interceptions. Cam Newton is 29-32-1 career on the road and 1-5 against Seattle with five touchdowns and four interceptions. In primetime Newton is 8-11 in his career while Wilson is 25-7-1. Wilson is playing strong and has all his weapons around him including former Panther Greg Olsen who will torch his former team for a couple of touchdowns along with Carson running a pair in as the Seahawks win 31-20 to start the year 2-0. Play Seattle

Green Bay destroyed Minnesota on the road last week 43-34 as Rodgers threw for over 360 yards and for four touchdowns as he targeted Adams for 14 catches, 156 yards and two touchdown as they host another division for in the Lions. Detroit is coming off a blown lead in the fourth to Chicago allowing 21 points in the fourth quarter to lose 27-23. Stafford had 297 yards passing, a touchdown, an interception and was sacked once. Newly signed Adrian Peterson did have 93 yards on 14 carries. Rodgers is 71-18-1 in his career at home and 15-5 in his career against the Lions. Stafford is 29-44-1 on the road and 7-11 against Green Bay in his career. Look for a shoot out early with Green Bay defense stepping up in the second half for an easy victory for the Packers 38-23. Play Green Bay